NUMERICAL SIMULATION IN DESIGN OF ARBITRARY-SHAPE 3D MULTIFUNCTIONAL INTEGUMENTARY CARDIAC MEMBRANES
Zhuangjian Liu1, Yewang Su2, Lizhi Xu3
1Institute of High Performance Computing, A*STAR, Singapore;
2Institute of Mechanics, Chinese Academy of Sciences, China;
3University of Michigan, USA
Multiparametric physiological mapping and stimulation can play an important role in both basic and clinical cardiology. A conformal electronic system, known as 3D multifunctional integumentary membranes (3D-MIMs), is developed using 3D elastic membranes shaped precisely to match the epicardium of the heart. This device is fabricated using 3D printing to create a platform for deformable arrays of multifunctional sensors, electronic and optoelectronic components. The integumentary devices are made to completely envelop the heart, thus providing conformal interfaces to all points on the heart as well as providing a mechanically stable biotic/abiotic interface during normal cardiac cycles. Numerical simulation is then performed to serve as a key parameter to evaluate the device designs. Also, a universal and easy-to-use model is developed to calculate the average pressure associated with integration of 3D-MIMs on the arbitrary organ shape. The average pressure is expressed in terms of the surface area and volume of the heart, apart from the material parameters and expansion strain. The prediction from this model agrees well with the results obtained from numerical simulation. These approaches provide a simple way to quantify the average pressure imposed by the devices as well as allow for design of high-definition implantable devices for diagnostics and therapy of lethal heart diseases.