COMPUTATIONAL ANALYSIS OF VASCULAR HEMODYNAMICS AND VENTRICULAR MECHANICS IN PULMONARY ARTERIAL HYPERTENSION
Lik Chuan Lee1, Ce Xi1, Byron Zambrano1, Liang Zhong2, Ju-Le Tan2, Seungik Baek1
1Michigan State University, USA;
2National Heart Centre Singapore, Singapore
Pulmonary arterial hypertension (PAH) is a complex cardiovascular disease that is associated with an elevated pressure in the pulmonary arterial system. Prolonged exposure to high pressure in pulmonary system produces structural and geometrical changes in both the right ventricle and the pulmonary vasculature. Here, we describe an image-based computational modeling pipeline to analyze patientspecific ventricular mechanics and vascular hemodynamics that are associated with PAH. Using magnetic resonance images and in vivo pressure measurements, we developed computational models and methods to describe biventricular mechanics as well as the (fluid-structure) interaction between hemodynamics and pulsatile wall motion of the pulmonary vasculature in PAH patients. These models were used to quantify ventricular strain field, regional ventricular mechanical properties (passive stiffness and myocardial contractility), myofiber stress, vascular flow field, wall shear stress, oscillatory shear index and pulmonary arterial compliance. We show that these quantities are substantially different from those found in a healthy subject, suggesting that long-term remodeling caused by PAH leads to abnormality in both ventricular and arterial wall mechanics, as well as vascular hemodynamics.