ROLE OF MECHANICAL FORCE FEEDBACK IN MULTICELLULAR MORPHOGENESIS: IN SILICO AND IN VITRO STUDIES
Kyoto University, Japan
Mechanical forces play important roles in living tissues and organs to determine their functional shape and structure. In this presentation, by illustrating examples of multicellular morphogenesis, we will discuss how locally generated mechanical forces and their feedback result in the macroscopic regulation of tissue/organ morphology, and how such multiscale approach based on modeling and simulation allows us to explore the roles of mechanical force feedback in determining the organ-level functional shapes.
In multicellular morphogenesis, tissue folding is controlled by local mechanical forces such as contractile (tensile) forces generated in actinmyosin networks and pushing (compressive) forces due to tissue volumetric increase by cell division and proliferation. Mechanical forces are sensed at microscopic cellular and molecular levels and integrated to determine the macroscopic tissue/organ morphology through multiscale interactions. To better understand such complex multiscale phenomena, mathematical modeling and computer simulation based on mechanics will give us a useful framework for conducting in silico experiments by combining with in vitro experiments.