B6: Cardiovascular Mechanics II

ELECTROSPUN COMPOSITE SCAFFOLDS FOR CARDIOVASCULAR TISSUE ENGINEERING

Selami Çakmak1, Mehmet Onur Aydogdu2, Esra Altun2, Nazmi Ekren3, Oguzhan Gunduz3

1Gata Military Medical Academy, Turkey;
2Institute of Pure and Applied Sciences, Marmara University, Turkey;
3Faculty of Technology, Turkey


Introduction.
Electrospinning is a popular method to produce composite nanofiber structures with using polymeric substances for a variety of applications such as tissue engineering and other biomedical applications [1]. Polycaprolactone (PCL) is one of the most preferred synthetic polymers for Electrospinning Technique due to its features such as having high mechanical properties, being biodegradable and easiness of the process [2]. Polymer blending is also contributes to the properties of the electrospun scaffolds. Blending a synthetic polymer together with a natural polymer may enhance the properties of the electrospun scaffolds by benefiting from their individual advantages [3].

Experimental.
In this study, electrospinning technique (Fig.1) was used to produce nanocomposite structures for possible applications in cardiovascular tissue engineering using PCL, Ethyl Cellulose and Collagen. Produced samples were characterized by SEM, tensile strength and thickness measurements MTT assays, in-vivo, and in-vitro. Results are also supported with FT-IR and DSC analyses.

Results and Discussion. According to the test results using the synthetic polymer with the natural one to create new hybrid nanofiber structure increased mechanical and chemical properties of the material. Also presence of the Human Collagen which is a natural protein quite often found in the human body causes the composite nanofiber scaffolds to be more biocompatible, bioabsorbable and more desirable results from the in-vitro and in-vivo tests.

Conclusions. Nanofibrous scaffolds obtained are promising to use in cardiovascular tissue engineering.

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