B5: Cardiovascular Mechanics I


Yen Ngoc Nguyen1, Edgar Tay1,2, Hwa Liang Leo3

1National University of Singapore, Singapore;
2Loo Lin School of Medicine, NUS;
3Biofluid Mechanics Research Lab, National University of Singapore, Singapore

Recently, there has been a renewed interest in characterizing intraventricular flow patterns in different physiological and pathological conditions. Flow hemodynamics, especially the vortex structure formed and evolved inside ventricular chamber, has been linked to cardiac efficiency and adaptation. In this new perspective, flow alterations due to different cardiovascular procedures can affect the corresponding long-term outcome of these treatments. Especially, repairs and replacements performed on atrioventricular valves to treat valvular regurgitation are likely to exert direct impact on intra-ventricular flow pattern. Despite limited attempts to quantify flow patterns inside the left ventricle after mitral valve replacement and repair, similar flow description for the right side of the heart is currently lacking. In this study, a novel in vitro experimental mock circulatory system mimicking the right heart circulation was built to investigate hemodynamics of the right ventricle following different tricuspid regurgitation therapies. Particle Imaging Velocimetry was performed to visualize flow velocity field and quantify different hemodynamic parameters. The results provides a comparative analysis of the hemodynamic efficiency of different tricuspid valve replacement strategies to treat tricuspid regurgitation. The knowledge could encourage more effective pre-operative planning and better outcomes for current clinical practices.

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